Changes in kisspeptin,Growth and thyroid hormones in thalassemic patients of pubertal age group

Beta thalassemia syndrome are a group of hereditary blood disorders in which or absent beta globin chain synthesis,results in reduced hemoglobin,decreased rbc production and anemia. total 300 individuals were divided into 4 groups according to age and gender i.e ≤13 years females,>13 years females,≤13 years and >13 years males. height in centimeter,weight in kilogram was measured to calculate bmi kg/m2. serum ferritin (ng/ml) and hemoglobin (gm/dl) alongwith hormonal assay of gh (ng/ml),t3 (ng/ml),t4(μg/dl),tsh (μiu/ml),and kisspeptin (ng/ml) was done. bmi and hemoglobin were significantly reduced (p<0.001),while serum ferritin were significantly increased (p>0.001) in all four thalassemic groups on comparison with control. kisspeptin levels were significantly reduced in ≤13 years female (p≤0.001). while significantly high levels were observed in >13 years of male (p<0.01). t3 levels were significantly increased in both thalassemic groups of female (p>0.01). while t4 levels were significantly reduced in ≤13 years of male alongwith significantly reduced (p>0.05) tsh levels. in <13 years male significantly increased (p<0.01) tsh levels were obtained. growth hormone levels were significantly reduced (p<0.001) in both male and female thalassemic groups of ≤13 years. while significantly raised (p<0.001) hormone levels were observed in male and female thalassemic groups of >13 years. in >13 thalassemic female t3 had a negative correlation (p<0.05) with bmi and hemoglobin,while a positive correlation (p<0.001) of t3 with hemoglobin was observed in thalassemic male of ≤13 years. in >13 years male t3 had a positive correlation (p<0.05) with kisspeptin. t4 in all four thalassemic groups had a significant positive correlation with hemoglobin (p<0.05). tsh in >13 years female had a significant positive correlation with bmi,ferritin and hemoglobin (p<0.001). results revealed that hypothalamic pituitary axis had proper production,other factors miught be involved in delaying the growth spurt. copyright 2017 zoological society of pakistan.