Evidence of clinicopathological changes during equine Leptospirosis

Leptospirosis is a globally spread zoonotic disease effecting a wide range of animal species and humans. 18 leptospira positive horses based on elisa and 9 healthy horses were included in the study. blood profile,serum biochemistry and mineral profile were analyzed at day 0,7 and 21 of infection. results showed significant decrease (p<0.05) in red blood cells (rbc),packed cell volume (pcv),hemoglobin (hb),mean corpuscular hemoglobin concentration (mchc) and platelets while total leucocytes count (tlc),neutrophils,eosinophils,basophils,lymphocytes,monocytes,red cell distribution width (rdw) and mean corpuscular volume (mcv) were increased significantly (p < 0.05) which indicated hemolytic anemia. while,serum biochemistry showed significant elevation in alanine transaminase (alt),aspartate aminotransferase (ast),alkaline phosphatase (alp),blood urea nitrogen (bun) and creatinine which indicate renal and liver damage. concentration of na,k,ca,mg,p,cu and zinc in serum were significantly decreased (p< 0.05),indicating tubular damage in kidneys. copyright 2017 zoological society of pakistan.