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Molecular effects of polymorphism in the 3'UTR of osteopontin gene in Riverine buffalo
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نویسنده
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manzoor s. ,nadeem a. ,babar m.e. ,shehzad w. ,hashmi a.s. ,imran m. ,hussain t. ,wajid a. ,javed m.
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منبع
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pakistan journal of zoology - 2017 - دوره : 49 - شماره : 4 - صفحه:1527 -1529
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چکیده
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Nucleotide sequencing of bovine osteopontin gene showed a novel dna polymorphism 37421762 (c>a) in the 3'-untranslated region (3'-utr) of the gene. association test was performed to analyze its relation with milk composition but it was found non-significant in all analyzed traits. so,it was inferred that it might be due to environmental or epigenetic effect,sampling number or a breed difference. to know the functional consequences of the identified polymorphism,rna secondary structure analysis was performed and snp was found changing the termination loop shape in mrna. however,to increase the selection efficacy of dairy animals,the effects of candidate polymorphism should further be screened in different environments and genetic backgrounds. copyright 2017 zoological society of pakistan.
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کلیدواژه
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3'UTR; Osteopontin gene; Polymorphism; Riverine buffalo
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آدرس
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institute of biochemistry and biotechnology,university of veterinary and animal sciences,lahore, Pakistan, institute of biochemistry and biotechnology,university of veterinary and animal sciences,lahore, Pakistan, virtual university of pakistan,lahore, Pakistan, institute of biochemistry and biotechnology,university of veterinary and animal sciences,lahore, Pakistan, institute of biochemistry and biotechnology,university of veterinary and animal sciences,lahore, Pakistan, institute of biochemistry and biotechnology,university of veterinary and animal sciences,lahore, Pakistan, virtual university of pakistan,lahore, Pakistan, institute of biochemistry and biotechnology,university of veterinary and animal sciences,lahore, Pakistan, institute of biochemistry and biotechnology,university of veterinary and animal sciences,lahore, Pakistan
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Authors
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