Non-monotonic endocrine-disrupting effects of bisphenol-a on vitellogenin expression in juvenile freshwater cyprinid,Catla catla

Endocrine-disrupting chemicals e.g. bisphenol-a can alter fish reproduction. vitellogenin (vtg) is the egg yolk precursor and used as a biomarker for estrogenic endocrine disruption. to elucidate the endocrinedisrupting effect of bisphenol-a,juvenile catla catla was exposed to graded concentrations of bisphenol-a (10,100,1000μg/l) for 14 days. bpa exposure strongly elevates vtg mrna level in fish exposed to 100μg/l but at 1000 μg/l exposure of bpa,vtg level decreased compared to 100μg/l exposed fish. these results showed that bpa has estrogenic action and cause endocrine disruption in juvenile c. catla at environmentally relevant concentration. moreover,these results also depict the non-monotonic,biphasic dose response to bpa. copyright 2017 zoological society of pakistan.