Antimicrobial and antioxidant screening of N'-substituted sulphonyl and benzoyl derivatives of 4-Pyridine carboxylic acid hydrazide

In this research program,the antibacterial,antifungal and antioxidant activities of six n-substituted sulfonyl and benzoyl derivatives of lead molecule pch were reported. out of these compounds,sulphonyl derivatives 2,3 and benzoyl derivative 5 showed moderate to good activity against different strains of gram-positive and gram-negative bacteria including b. cereus,b. subtilis,b. thruingiensis and s. pyogenes,s. fecalis and e. coli atcc 8739. moreover,upon antifungal screening,the compound,n′-[(2,4,6-trimethylbenzene) sulfonyl]pyridine-4-carbohydrazide possessed good antifungal activity against candida species,a causative agent of systemic fungal infections. antioxidant study demonstrated more than 50% inhibition in dpph assay for sulphonyl derivative 2 indicating its potential as antioxidant while the other derivatives expressed low level of radical scavenging property.