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Cytotoxic flavonoids from the young twigs and leaves of Caesalpinia bonduc (Linn) Roxb
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نویسنده
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ogunlana o.o. ,he w.j. ,fan j.t. ,zeng g.z. ,ji c.j. ,zheng y.q. ,olagunju j.a. ,akindahunsi a.a. ,tan n.h.
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منبع
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pakistan journal of pharmaceutical sciences - 2015 - دوره : 28 - شماره : 6 - صفحه:2191 -2198
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چکیده
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The extraction,fractionation and recognition of flavonoids from the ethanolic extract of young twigs and leaves of c. bonduc were carried out. in addition,cytotoxic study of the flavonoids on two cancer cell lines,bgc-823 and hela was carried our using sulphorhodamine b assay. seven flavonoids,six of which are being reported for the first time in this plant,were isolated. their structures were identified by ms and nmr spectroscopic methods. petroleum ether,ethyl acetate and water fractions exhibited moderate cytotoxic activity against hela cells. five compounds showed cytotoxic activity against hela cell in comparison with paclitaxel,while only one compound showed a good degree of cytotoxic activity against bgc-823 cell in comparison to paclitaxel. the results obtained showed a structure - activity relationship.
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کلیدواژه
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Caesalpinia bonduc; Cytotoxic activity; Flavonoids
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آدرس
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department of biological sciences,college of science and technology,covenant university,pmb 1023,ota, Nigeria, state key laboratory of phytochemistry and plant resources in west china,kunming institute of botany,chinese academy of sciences,kunming, China, state key laboratory of phytochemistry and plant resources in west china,kunming institute of botany,chinese academy of sciences,kunming, China, state key laboratory of phytochemistry and plant resources in west china,kunming institute of botany,chinese academy of sciences,kunming, China, state key laboratory of phytochemistry and plant resources in west china,kunming institute of botany,chinese academy of sciences,kunming, China, state key laboratory of phytochemistry and plant resources in west china,kunming institute of botany,chinese academy of sciences,kunming, China, department of medical biochemistry,faculty of basic medical sciences,college of medicine,lagos state university,ikeja, Nigeria, department of biochemistry,federal university of technology, Nigeria, state key laboratory of phytochemistry and plant resources in west china,kunming institute of botany,chinese academy of sciences,kunming, China
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Authors
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