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Biotransformation of swertiamarin by Aspergillus Niger
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نویسنده
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chang j. ,zhou b.
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منبع
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pakistan journal of pharmaceutical sciences - 2015 - دوره : 28 - شماره : 6 - صفحه:1933 -1937
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چکیده
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The biotransforamtion of swertiamarin has been carried out using aspergillus niger. the results showed that 60% swertiamarin were metabolized into two metabolites during the 5 days of biotransformation. the metabolites were identified as erythrocentaurin and 5-ethylidene-8-hydroxy-3,4,5,6,7,8-hexahydro-1hpyrano[3,4-c]-pyridine-1-one,a novel alkaloid,with nmr and ms. the hydrolysis of glucosidic bond catalyzed by β-d-glucosidase was found to be the rate-limiting reaction in pathway of biotransformation of swertiamarin.
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کلیدواژه
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5-ethylidene-8-hydroxy-3 ,8-hexahydro-1Hpyrano[3 ,4-c]-pyridine-1-one; Aspergillus Niger; Biotransformation; Erythrocentaurin; HPLC; NM; Solid phase extraction; Swertiamarin
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آدرس
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school of science life,jiangxi science and technology normal university, China, school of pharmacy,jiangxi science and technology normal university, China
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Authors
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