Preparation,biodistribution and scintigraphic evaluation of 99mTc-lincomycin

A complex of lincomycin was synthesized with technetium-99m. the synthesis was carried out by using sncl2.2h2o as reducing agent and ascorbic acid as stabilizer. the effect of various parameters such as amount of ligand/reducing agent,ph value and reaction time on radio labeling process was studied. the characterization of the 99mtc-lincomycin was performed by hplc and electrophoresis biodistribution studies were carried out by analyzing the model of bacterial infectious rats (sprague-dawley). the uptake of infectious lesions at different time interval was also studied by using scintigraphic technique. the complex showed effective target to non-target ratio for various inflammatory or infectious lesions. the 99mtc-lincomycin effective binding to living bacteria and could be used successfully as an infection imaging agent.