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Comparative anti-glycation and α-glucosidase inhibition studies of microbial transformed compounds of dydrogesterone
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نویسنده
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azizuddin department of chemistry ,rasheed s. ,naz s. ,naheed s. ,choudhary m.i.
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منبع
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pakistan journal of pharmaceutical sciences - 2015 - دوره : 28 - شماره : 2 - صفحه:521 -523
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چکیده
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Anti-glycation and α-glucosidase inhibition activities of microbial transformed compounds of dydrogesterone (1); 20r-hydroxy-9β,10α-pregna-4,6-diene-3-one (2),17β-hydroxy-9β,10α-androsta-4,6-diene-3-one (3) and 9β,10α- androsta-4,6-diene-3,17-dione (4) were evaluated. compounds 1 and 4 showed potent α-glucosidase inhibitory activities,while 2 and 3 were found to be weak inhibitors,whereas anti-glycation activities of 1-4 were not observed.
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کلیدواژه
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Anti-glycation; Dydrogesterone; Microbial transformation; α-glucosidase inhibition
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آدرس
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gulshan-e-iqbal campus,federal urdu university of arts science and technology, Pakistan, h.e.j. research institute of chemistry,international center for chemical and biological sciences, Pakistan, department of chemistry,gulshan-e-iqbal campus,federal urdu university of arts science and technology, Pakistan, department of biotechnology,jinnah university for women,5-c,nazimabad, Pakistan, h.e.j. research institute of chemistry,international center for chemical and biological sciences, Pakistan
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Authors
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