Improvement on solubility of fluticasone propionate with cyclodextrins by mechanochemical activation

To enhance the solubility and in vitro dissolution of fluticasone propionate (fp),a novel approach was developed with mechanochemical treatment. the order of solubilizing effect of β-cd derivatives was observed as hp-β-cd-sbe-β-cd-β-cd-he-β-cd,consequently,hp-β-cd showed the highest stability constant. to further improve fp solubility,fp and hp-β-cd were grinded using a roll mill,the optimal conditions,determined through single factor experiments,were as follows: rotation frequency of 60 hz; milling time of 6h. mass ratio of 1: 7. in comparison with pure fp,a 280-fold increase in solubility and a 2.15-fold higher dissolution rate of ground mixture was obtained. the characterization of fp and hp-β-cd complexes had been analyzed by scanning electron microscopy (sem),differential scanning calorimetry (dsc),powder x-ray diffractometry (pxrd) and fourier transform infrared spectroscopy (ft-ir). the results suggested that the interaction between fp and hp-β-cd was strengthened and an amorphous ground mixture was gained. after stored for 60 days,the ground mixtures were stable both chemically and physically.