Role of Ki-67 in acromegalic patients with hyperprolactinemia: retrospective analysis in 61 Chinese Patients

To evaluate the specific characteristics in acromegalic patients with hyperprolactinemia by analyzing the differences between patients with different ki-67 values. between 2002 and 2010,a set of data on 61 patients undergoing transsphenoidal surgery was available at the department of neurosurgery,provincial hospital affiliated to shandong university. patients were divided into ki-67 >3% group and <3% group. a retrospective analysis of clinical,hormonal,immunohistochemical,and imaging was observed in all patients. there were no significant differences in age,gender,tumor size and apoplexy between the two groups. time interval in ki-67 ≥3% group was longer than <3% group (p=0.037). patients in ki-67 >3% group had a higher rate of invasiveness (p=0.048),higher incidences of diabetes mellitus (p=0.036),coarse facial features (p=0.048),large hands and feet (p=0.003),higher gh levels (p<0.05),higher diabetes insipidus rate (p<0.001),and more frequent recurrence (p=0.011) than ki-67 <3% group. patients with higher ki-67 value harbored longer time interval,more aggressive tumors,more acromegaly manifestations,higher gh level,and higher recurrence than patients with lower ki-67 value.