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A novel β-lactam derivative,albactam from the flowers of Albizia lebbeck with platelets anti-aggregatory activity in vitro
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نویسنده
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el-gamal a.a. ,abd-el-halim m.f. ,kalil a.t. ,basudan o.a. ,al-rehaily a.j. ,ahmad m.s. ,el-tahir k.h. ,al-massarani s.m. ,abdel-mageed w.m.
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منبع
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pakistan journal of pharmaceutical sciences - 2015 - دوره : 28 - شماره : 2 - صفحه:745 -753
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چکیده
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A novel β-lactam derivative,albactam,was isolated from the alcoholic extract of the flowers of albizia lebbeck. it showed a significant anti-aggregatory activity against adenosine diphosphate and arachidonic acid induced guinea-pigs' platelets aggregation in vitro. six more known compounds were also isolated and fully characterized by measuring 1d and 2d nmr,two of them are the triterpenes β-amyrin and 11α,12α-oxidotaraxerol,two ceramide derivatives and two flavonoids,kampferol 3-o-rutinoside and rutin.
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آدرس
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pharmacognosy department,faculty of pharmacy,king saud university,riyadh,saudi arabia / pharmacognosy department,faculty of pharmacy,mansoura university, Egypt, pharmacognosy department,faculty of pharmacy,king saud university, Saudi Arabia, pharmacognosy department,faculty of pharmacy,king saud university,riyadh,saudi arabia / pharmacognosy department,faculty of pharmacy,mansoura university, Egypt, pharmacognosy department,faculty of pharmacy,king saud university, Saudi Arabia, pharmacognosy department,faculty of pharmacy,king saud university, Saudi Arabia, pharmacognosy department,faculty of pharmacy,king saud university, Saudi Arabia, pharmacology department,facultyof pharmacy,king saud university, Saudi Arabia, pharmacognosy department,faculty of pharmacy,king saud university, Saudi Arabia, pharmacognosy department,faculty of pharmacy,king saud university, Saudi Arabia
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Authors
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