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Anticancer activity of Cinnamon tamala leaf constituents towards human ovarian cancer cells
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نویسنده
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shahwar d. ,ullah s. ,khan m.a. ,ahmad n. ,saeed a. ,ullah s.
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منبع
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pakistan journal of pharmaceutical sciences - 2015 - دوره : 28 - شماره : 3 - صفحه:969 -972
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چکیده
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Bioassay guided fractionation of cinnamon tamala leaf extracts yielded bornyl acetate (1),caryophylene oxide (2),p-coumaric acid (3) and vanillic acid (4) using a-2780 human ovarian cancer cell lines. the structures of the isolated compounds were confirmed through spectroscopic techniques (eims,1h and 13c nmr). compound 1 exhibited highest cytotoxicity with 90.16±1.06% inhibition (ic50=5.30 × 10-4 mg/ml) followed by compound 2 (84.40±1.53% inhibition; ic50=8.94 × 10-3 mg/ml),while compounds 3 and 4 were inactive in the bioassay. © 2015,pakistan journal of pharmaceutical sciences. all rights reserved.
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کلیدواژه
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A-2780 and cytotoxicity; Anticancer; Cinnamon tamala
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آدرس
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research lab. ii,department of chemistry,gc university, Pakistan, research lab. ii,department of chemistry,gc university,lahore,pakistan,department of chemistry,university of gujrat,hafiz hayat campus, Pakistan, research lab. ii,department of chemistry,gc university, Pakistan, research lab. ii,department of chemistry,gc university, Pakistan, research lab. ii,department of chemistry,gc university, Pakistan, research lab. ii,department of chemistry,gc university, Pakistan
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Authors
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