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Potential antibacterial activity of coumarin and coumarin-3-acetic acid derivatives
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نویسنده
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chattha f.a. ,munawar m.a. ,mehr-un-nisa institute of chemistry ,ashraf m. ,kousar s. ,arshad s.
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منبع
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pakistan journal of pharmaceutical sciences - 2015 - دوره : 28 - شماره : 3 - صفحه:819 -823
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چکیده
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Coumarin and coumarin-3-acetic acid derivatives were synthesized by reacting phenols with malic acid,ethyl acetoacetate and ethyl acetylsuccinate in appropriate reaction conditions. all synthesized compounds were subjected to test for their antimicrobial activities against variety of gram positive (bacillus subtilis,staphylococcus aureus) and gram negative bacterial stains (shigella sonnei,escherichia coli) by agar dilution method. several of them exhibited appreciable good antibacterial activity against the different strains of gram positive and gram negative bacteria. these findings suggest a great potential of these compounds for screening and use as antibacterial agents for further studies with a battery of bacteria. © 2015,pakistan journal of pharmaceutical sciences. all rights reserved.
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کلیدواژه
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Antibacterials; Coumarin-3-acetic acid; Coumarins; Minimum inhibition concentration
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آدرس
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institute of chemistry,university of the punjab, Pakistan, institute of chemistry,university of the punjab, Pakistan, university of the punjab, Pakistan, department of biochemistry and biotechnology,islamia university of bahawalpur, Pakistan, institute of chemistry,university of the punjab, Pakistan, college of conventional medicine,islamia university of bahawalpur, Pakistan
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Authors
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