In vivo anti-inflammatory,analgesic and antipyretic activities of a medicinal plant,Caesalpinia bonducella F

This research examined antipyretic,anti-inflammatory,and analgesic activities of ethanolic extract of c. bonducella whole seeds in experimental albino rats. three doses,100,200 and 400 mg/kg of the whole seed ethanolic extract prepared as a suspension in 2 ml of 2% gum acacia were used. acute inflammatory and antipyretic activities were evaluated in experimental animals by carrageenan induced paw edema and brewer's yeast-induced pyrexia models,respectively. a significant (p<0.05) reduction in paw volumes,and pyrexia was noted in experimental animals when compared with control animals. the ethanol see extract (400 mg/kg) displayed in vivo anti-inflammatory,antipyretic and analgesic in terms of reduction in paw edema,% writhes inhibition and rectal temperature by (0.24±0.03),(31.38%) and (36.2±0.1),respectively. overall the whole ethanolic seed extract at all tested concentrations produced significant (p<0.05) anti-inflammatory,antipyretic and analgesic activities. the results obtained in this study clearly indicated the ethno-medicinal potential of c. bonducella in curing pain and inflammation related disorders,supporting its efficacy as a natural analgesic,antipyretic and anti-inflammatory agent.