The curative effect of adefovir dipivoxil treating HBeAg negative chronic hepatitis B and treating HBeAg positive chronic hepatitis B combining interferon α-2b

This study aimed to research the efficiency of adefovir dipivoxil in hepatitis b e antigen (hbeag)-negative chronic hepatitis b treatment and in combination with α-2b interferon in the treatment of hbeag-positive chronic hepatitis b. a total of 102 cases of adult patients with hbeag chronic hepatitis b were selected for testing. hbeag negative chronic hepatitis b patients took 10mg adefovir dipivoxil capsules once daily,while positive chronic hepatitis b patients were randomly divided into either a treatment group or a control group. the treatment group was administrated with 10mg adefovir dipivoxil capsules,1 time daily,and injected with 5 million u recombinant human interferon α-2b through muscle every other day. the control group was treated with 10mg adefovir dipivoxil capsules,1 time per day. we examined alanine aminotransferase (alt) normalization and the hepatitis b virus (hbv)-dna negative rate (undetectable rate),as well as,hbeag / hepatitis b e antibody (hbeab) sero-conversion rate to detect treatment effects. the results proved that after 6 months of medication therapy,the alt normalization rate was 49.9% and the hbv-dna negative conversion rate was 54.3%. 18 months into the treatment,showed an alt normalization rate of 73.2%,while the hbv-dna negative conversion rate grew to 76.8%. the use of adefovir dipivoxil treatment of the negative chronic hbv has a certain extent combined with α-2b interferon therapy in treatment of hbeag positive chronic hepatitis b. after a 48-week observation period,alt normalization and hbv-dna rate could not be measured,hbeag/hbeab sero-conversion rose higher,indicating that the treatment of the combined drugs is more efficient than taking adefovir dipivoxil by itself,and the data were comparable with the control group (p<0.05). thus adefovir dipivoxil can greatly improve the restrain function to hbv-dna and improve the immunity and control ability of the body,with obvious short-term effects,in combination with interferon.