Anti-nociceptive and anti-inflammatory activities of the extracts of Stauntonia chinensis

The aim of this investigation was to study the anti-nociceptive and anti-inflammatory activities of stauntonia chinensis (s. chinensis) and the possible action mechanisms of effective fractions. the anti-nociceptive and antiinflammatory activities of s. chinensis extracts, including the 60% etoh extract (ymg), the n-buoh extract (ymgb) and the aqueous residue (ymgw) of ymg, and the fractions from ymgb (ymgb1~ymgb7) were investigated by using the mouse acetic acid-induced writhing test and the rat formalin test. the effect of these extracts on the pge2 production was tested as well. in the mouse acetic acid-induced writhing test and the rat formalin test, ymgw and ymgb displayed anti-nociceptive and anti-inflammatory activities, suggesting that they were the active ingredients of ymg. among the fractions isolated from ymgb, ymgb1, ymgb3, ymgb4 and ymgb6 were the main active ingredients producing anti-nociceptive activity and ymgb3, ymgb5, ymgb6 and ymgb7 were the main active ingredients producing anti-inflammatory activity. additionally, ymgw, ymgb and its separations reduced the production of pge2, which might be the mechanism of them producing anti-inflammatory activity. these results demonstrated the active ingredients of s. chinensis producing anti-nociceptive and anti-inflammatory activities, which is valuable to validate the substance basis of s. chinensis’s pharmacological actions.