Evaluation and comparison of different brands of domperidone tablets available in Karachi, Pakistan

Domperidone is an anti-dopaminergic drug used for the treatment of nausea, vomiting and dyspepsia. it has also been used in parkinson’s disease. in this study, five different brands of domeperidone tablets were selected from the local market for evaluation of their quality as the local market is occupied of many competitors for a single generic. the evaluation of domperidone tablets was done using various pharmacopoeial and non-pharmacopoeial tests. all the test results fell within bp specified limits for all the selected brands i.e. the results for brands a to e for weight variation, thickness and diameter were satisfactory and within limits. for brands a to e, the results for hardness and friability were also satisfactory i.e. 4-10kg/cm2and 0.1-0.6% respectively. the results for brands a to e for disintegration were 2-6 minutes; for dissolution and assay, the results were 89-92% and 95-99% respectively. the results of similarity factor (f2)also showed that all brands of domperidone have comparative dissolution profiles.