Effect of renin inhibition on adipokines in diabetic rats

Insulin resistance predicts development of type 2 diabetes mellitus (dm). adipocytes release tumor necrosis factor-alpha (tnf-α), and adiponectin. they modulate whole-body insulin sensitivity. the disturbance in the relationship between good and bad adipokines may cause insulin resistance. the renin-angiotensin aldosteron system (raas) plays a role in dm and the consequence of cardiovascular complications development. it is considered as a target for therapy. the present objective examined the relationship between renin angiotensin system and dm. there were, group (1): normal non obese rats, group (2): obese diabetic rats, group (3) : obese diabetic rats with telmisartan, group (4): obese diabetic rats with enalapril, group (5): obese diabetic rats with aliskiren. there was a significant increase in serum glucose, lipid profile [triglycerides (tgs), low-density lipoprotein cholesterol (ldl), total serum cholesterol (tc)], tumor necrosis factor-alpha (tnf-α), malondialdehyde (mda) and a significant decrease in adiponectin associated with minor changes in superoxide dismutase (sod) activity in the obese diabetic rats. administration of telmisartan, enalapril and or aliskiren caused a significant improvement in serum lipid profile and adiponectin, a minor improvement in sod activity, a decrease in tnf- α and or mda. conclusion: renin angiotensin blockers significantly improve the metabolism and oxidative dysfunctions in type 2 dm and aliskiren may show a promising powerful therapy.