Anti-HIV-1 activities of extracts and phenolics from Smilax china L.

Four extracts (etoh, chcl3, etoac, and buoh) and five phenolics (dihydrokaempferol (1), resveratrol (2), kaempferol-7-o-β-d-glucoside (3), dihydrokaempferol-3-o-α-l-rhamnoside (4), oxyresveratrol (5)) from smilax china l. was evaluated for anti-hiv-1 activities and cytotoxicity activities in vitro. all these extracts and phenolics showed lower or no cytotoxicity at a concentration ranged from 0.8 μg/ml to 100 μg/ml, but some showed potential anti-hiv-1 activities, that is, buoh extract and compound 2 showed higher anti-hiv-1 activities than other extracts and compounds in the tested concentrations. etoac extract and compound 1 and 3 showed moderate anti-hiv-1 activities at a concentration higher than 4 μg/ml. in the end, the structure-activity relationship of four extracts and five phenolics was discussed.