In vitro anti-proliferative and anti-inflammatory activity of leaf and fruit extracts from Vaccinium bracteatum Thunb.

The aim of this study was to evaluate in vitro anti-proliferative (tested on mcf-7, mda-mb-231, and mcf- 10a cell lines) and anti-inflammatory (evaluated as inhibition of prostaglandin e2 synthesis catalyzed by cyclooxygenase-2) effect of various extracts from vaccinium bracteatum leaves and fruits. the highest anti-proliferative effect possessed leaf dichloromethane extract with ic50 values ranging from 93 to 198 μg/ml. in the case of cyclooxygenase-2 inhibition, n-hexane, dichloromethane, and ethanol fruit extracts showed the best activity with ic50 values = 2.0, 5.4, and 12.7 μg/ml, respectively. these results indicate that v. bracteatum leaves and fruits could be useful source of anti-cancer and anti-inflammatory compounds.