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Synthesis, characterization and biological screening of sulfonamides derived form 2-phenylethylamine
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نویسنده
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Aziz-ur-Rehman ,Afroz Sumbel ,Abbasi Muhammad Athar ,Tanveer Wajeeha ,Khan Khalid Mohammed ,Ashraf Muhammad ,Ahmad Irshad ,Afzal Iftikhar ,Ambreen Nida
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منبع
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pakistan journal of pharmaceutical sciences - 2012 - دوره : 25 - شماره : 4 - صفحه:809 -814
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چکیده
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In the present study, a series of n-substituted derivatives of 2-phenylethylamine has been synthesized. the reaction of 2-phenylethylamine (1) with benzene sulfonyl chloride (2) yielded n-(2-phenylethyl) benzenesulfonamide (3), which further on treatment with alkyl/acyl halides (4a-i) in the presence of sodium hydride furnished into nsubstituted sulfonamides (5a-i). these derivatives were characterized by ir, 1h-nmr and ei-ms and then screened against acetyl cholinesterase (ache), butyryl cholinesterase (bche) and lipoxygenase enzyme (lox) and were found to be potent inhibitors of butyryl cholinesterase only.
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کلیدواژه
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2-phenylethylamine ,sulfonamides ,butyryl cholinesterase ,1H-NMR and EI-MS.
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آدرس
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Government College University, Department of Chemistry, Pakistan, Government College University, Department of Chemistry, Pakistan, Government College University, Department of Chemistry, Pakistan, Government College University, Department of Chemistry, Pakistan, University of Karachi, HEJ Research Institute of Chemistry, International Center for Chemical and Biological Sciences, Pakistan, Islamia University of Bahawalpur, Department of Biochemistry and Biotechnology, Pakistan, Islamia University of Bahawalpur, Department of Pharmacy, Pakistan, Islamia University of Bahawalpur, Department of Pharmacy, Pakistan, University of Karachi, HEJ Research Institute of Chemistry, International Center for Chemical and Biological Sciences, Pakistan
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Authors
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Aziz-ur-Rehman
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