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Behavioral and neurochemical profile of some novel phenacyl based isonipecotamide derivatives
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نویسنده
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Akhtar Shamim ,Arif Muhammad ,Mushtaq Nousheen ,Saify Zafar Saeed ,Ahmed Ahsaan ,Haleem Darakhshan Jabeen ,Akram Arfa
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منبع
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pakistan journal of pharmaceutical sciences - 2012 - دوره : 25 - شماره : 4 - صفحه:705 -713
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چکیده
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Study of natural products led to the development of new molecules of potential biological activity. piperidine nucleus constitutes one of the components of various alkaloids and drugs. during the course of our project regarding the synthesis of derivatives of piperidine carboxamide to study the effects of these compounds as anti-depressive agents, some of the compounds exhibited significant effects at all three doses, through open field activity thus establishing a direct relationship between dose and locomotion. moreover, these compounds have also shown the decreased level of 5- ht alone with increased level of dopamine as an indication of their antagonism towards 5-ht receptor.
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کلیدواژه
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Neurochemical Profile ,neurotransmitters ,biogenic amines ,catecholamine ,indolamine ,antagonism ,depression.
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آدرس
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University of Karachi, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Pakistan, University of Karachi, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Pakistan, University of Karachi, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Pakistan, University of Karachi, HEJ Research Institute of Chemistry, Pakistan, University of Karachi, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Pakistan, University of Karachi, Centre of Neuropharmacology, Department of Biochemistry, Pakistan, Federal Urdu University of Arts, Science and Technology, Pakistan
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Authors
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