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Enzyme inhibition, antioxidant and antibacterial potential of vasicine isolated from Adhatoda vasica Nees
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نویسنده
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Shahwar Durre ,Raza Muhammad Asam ,Tariq Sidra ,Riasat Madiha ,Ajaib Mohammad
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منبع
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pakistan journal of pharmaceutical sciences - 2012 - دوره : 25 - شماره : 3 - صفحه:651 -656
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چکیده
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Vasicine (1) was isolated from the ethanolic extract of adhatoda vasica nees (acanthaceae) and the structure was confirmed using spectroscopic techniques. acetylcholine esterase, trypsin, dpph inhibition potential and frap assay were carried out using in vitro models. the results showed 38.4 ± 1.2% and 37.4 ± 1.1% activity in acetylcholine and trypsin inhibition assays respectively. the compound (1) exhibited significant dpph inhibition activity (70.4 ± 1.3%, ic50 = 212.3 ± 1.9 μm). a dose dependant behavior of vasicine (1), was indicated in the frap assay. antibacterial activity was checked according to agar well diffusion assay and results revealed that vasicine (1) showed moderate activity.
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کلیدواژه
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Acetylcholine esterase ,Adhatoda vasica ,DPPH ,FRAP ,trypsin ,agar well diffusion assay.
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آدرس
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Government College University, Department of Chemistry, Research Lab II, PAKISTAN, University of Gujrat, Hafiz Hayat Campus, Department of Chemistry, PAKISTAN, Government College University, Department of Chemistry, Research Lab II, Pakistan, Government College University, Department of Chemistry, Research Lab II, Pakistan, Government College University, Department of Botany, Pakistan
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Authors
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