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Biological screening of Scrophularia nodosa extract and its fractions
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نویسنده
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Ahmad Mansoor ,Muhammad Noor ,Mehjabeen ,Jahan Noor ,Alam Syed Mahboob ,Ahmad Manzoor ,Obaidullah
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منبع
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pakistan journal of pharmaceutical sciences - 2012 - دوره : 25 - شماره : 2 - صفحه:307 -313
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چکیده
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Biological screening of scrophularia nodosa crude extract and its fractions (hexane, chloroform, ethyl-acetate, n-butanol and aqueous) was carried out on phytotoxicity, cytotoxicity, antibacterial, antifungal and analgesic activities. crude extract and its fractions produced 50-100% phytotoxicity at 1000μg/ml concentration whereas 25-77% phytotoxicity was observed at 10μg/ml concentration. the fractions exhibited significant antibacterial and antifungal effects. the non-toxic results of this plant were recorded in brine shrimps bioassay method at all concentrations. similarly no significant insecticidal activity was observed in crude extracts and fractions. analgesic activity results of s. nodosa in mice were found highly significant in crude extract as compared to fractions. in writhing test crude extract at 500 mg/kg showed 65.6% highest inhibitory response in mice.
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کلیدواژه
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S. nodosa ,antioxidant ,analgesic ,phytotoxic ,hemagglutination
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آدرس
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University of Karachi, Research Institute of Pharmaceutical Sciences, Department of Pharmacognosy, Pakistan, University of Karachi, Research Institute of Pharmaceutical Sciences, Department of Pharmacognosy, Pakistan, Federal Urdu University of Arts, Science & Technology, Department of Pharmacology, Pakistan, Dow University of Health Sciences, Dow College of Pharmacy, Department of Pharmacology, Pakistan, Jinnah Post Graduate Medical Center, Department of Pharmacology, Pakistan, University of Malakand, Department of Chemistry, Pakistan, University of Peshawar, Department of Pharmacy, Pakestan
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Authors
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Mehjabeen ,Obaidullah
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