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Evaluation of teratogenic effects of risperidone following simultaneous administration with antihypertensive and antiemetic drugs
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نویسنده
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Tauqeer Shaista ,Khan Rafeeq Alam ,Siddiqui Afaq Ahmed
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منبع
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pakistan journal of pharmaceutical sciences - 2012 - دوره : 25 - شماره : 1 - صفحه:261 -266
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چکیده
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Multiple drug administration is an important aspect of clinical practice particularly in specific physiological situation such as in neonates, elderly or pregnancy, since in all such situations, possibility of unwanted effects increases due to altered body physiology. in present study, the teratogenic effects of multiple drug administration risperidone, meclizine/pyridoxine and hydralazine have been compared with the teratogenic effects of individual drugs in pregnant mice. moreover the role of folic acid and α-tocopherol if any had also been investigated in reducing the teratogenic effects of these drugs in combination.
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کلیدواژه
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multiple drug administration ,teratogenic effects ,risperidone ,meclizine/pyridoxine ,hydralazine ,folic acid ,α- tocopherol
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آدرس
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University of Karachi, Faculty of Pharmacy, Department of Pharmacology, Pakistan, University of Karachi, Faculty of Pharmacy, Department of Pharmacology, Pakistan, University of Karachi, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Pakistan
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Authors
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