Development and evaluation of novel lozenges containing marshmallow root extract

Lozenges (tablets intended to be dissolved slowly in the mouth) were evaluated as delivery system for polysaccharides extract from althaea officinalis l. (marshmallow) root. the aim of investigation was to improve of the efficacy of convenient preparations for the treatment of irritated oropharyngeal mucosa and associated dry irritable cough. the formulations studied were prepared with water extract of roots of althaea officinalis l. the polysaccharides extract was obtained by ultrasonification. acute oral toxicity (ld 50 p.o.) of the obtained extract was estimated in mice. four models of lozenges based on different excipients were formulated. the characteristics of the preparations: resistance to crushing, friability testing, disintegration time and drug release properties were evaluated.