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SYNTHESIS AND EVALUATION OF MANNICH BASES OF BENZIMIDAZO [1,2-C] QUINAZOLIN- 6(5H)-THIONE FOR ANTIMICROBIAL ACTIVITY
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نویسنده
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SARASWATHI M ,ROHINI RM ,SINGH Rana Prathap ,NAYEEM NAIRA
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منبع
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pakistan journal of pharmaceutical sciences - 2010 - دوره : 23 - شماره : 4 - صفحه:459 -462
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چکیده
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The intermediate benzimidazo[1,2-c] quinazolin-6(5h)-thione (1) was obtained by cyclization of 2-(2’- aminophenyl) benzimidazole with carbon disulfide. mannich base (2a-d) of compound (1) was obtained on treatment with para formaldehyde and secondary aliphatic amines, similarly treatment of (1) with different ketones afforded respective mannich bases (3 e-h). all derivatives synthesized were characterized from ir and 1hnmr spectral data’s. moderate anti bacterial activity was exhibited from 2a-d and from 3f, 3h against s. aureus, e. coli, and e. fecalis but very negligent activity were seen from these compounds when screened against p aeruginosa
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کلیدواژه
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Mannich base ,Benzimidazo [1 ,2-c] quinazoline–6(5H)-thione ,antimicrobial activity
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آدرس
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Krupanidhi College of Pharmacy, Department of Pharmaceutical Chemistry, India, Krupanidhi College of Pharmacy, Department of Pharmaceutical Chemistry, India, Krupanidhi College of Pharmacy, Department of Pharmaceutical Chemistry, India, Krupanidhi College of Pharmacy, Department of Pharmaceutical Chemistry, India
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Authors
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