A COMPARATIVE STUDY OF ANTIOXIDANT VITAMINS AND SIMVASTATIN IN HYPERCHOLESTEROLIMIC RABBITS

The anti-lipidemic effects of orally administered antioxidant vitamins (vitamin a, vitamin c and vitamin e) individually and in combination were studied in cholesterol-fed rabbits and compared to the group of hypercholesterolemic animals that were treated with simvastatin. all treatment groups exhibited a decrease in serum total cholesterol, low density lipoprotein-cholesterol (ldl-c) and triglycerides concentrations, whilst vitamin c, vitamin e, the combination and simvastatin showed a more profound decrease in the lipid profile than vitamin a at different time intervals. the order of increase in high density lipoprotein-cholesterol (hdl-c) levels remained in favour of simvastatin, as none of the antioxidant vitamins treated group could exhibit a profound increase in the hdl-c.