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CYTOTOXICITY OF ISOLATED COMPOUNDS FROM THE EXTRACTS OF STRUCHIUM SPARGANOPHORA (LINN) KTZE ASTERACEAE
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نویسنده
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KASIM LATEEF SAKA ,FERRO VALERIE ,ODUKOYA OLUWAKEMI A ,UKPO GRACE EIGBIBHALU ,SEIDEL VERONIQUE ,GRAY ALEXANDER I ,WAIGH ROGER
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منبع
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pakistan journal of pharmaceutical sciences - 2011 - دوره : 24 - شماره : 4 - صفحه:475 -478
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چکیده
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Chemical investigation of the leaves of struchium sparganophora by the application of vlc, cl and ptlc resulted in isolation of three compounds. the cytotoxicity activity of these compounds on malignant human cultured cells was examined. vernodalin showed a significant cytotoxic activity on the melanoma and ovarian cancer cell lines (p<0.05) while the conjugated 3 methyl, 2, 6 hexacosedienol and luteolin caused cell death after 48h reculture without them. these compounds portend an effective remedy if subjected to structural modification to enhance its’ efficacy and the dietary importance of this plant as a culinary herb in west africa countries is evidence by the presence of these antitumour compounds in this plant.
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کلیدواژه
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Struchium sparganophora ,cytotoxicity ,luteolin ,vernodalin ,3 methyl ,6 hexacosedienol.
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آدرس
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Olabisi Onabanjo University, Faculty of Pharmacy, Nigeria, University of Strathclyde, Department of Immunology, UK, University of Lagos, Faculty of Pharmacy, Nigeria, University of Lagos, Faculty of Pharmacy, Nigeria, University of Strathclyde, Department of Pharmaceutical Sciences, UK, University of Strathclyde, Department of Pharmaceutical Sciences, UK, University of Strathclyde, Department of Pharmaceutical Sciences, UK
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Authors
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