ANTIDIABETIC AND HYPOLIPIDEMIC EFFECTS OF DIFFERENT FRACTIONS OF COCCINIA CORDIFOLIA L. ON NORMAL AND STREPTOZOTOCIN-INDUCED DIABETIC RATS

The present study was carried out to observe the antidiabetic and hypolipidemic effects of petroleum-ether, ethyl acetate and chloroform fractions isolated from ethanolic extract of the leaves of coccinia cordifolia linn. (150 mg/kg body weight) on normal and streptozotocin (stz)-induced diabetic rats for one day experiment. single doses (150 mg/kg, i.p.) of c. cordifolia extracts were given to normal and diabetic rats. the fasting blood glucose (fbg), serum triglyceride (tg) and serum total cholesterol (tc) levels were investigated in normal and stz-diabetic rats on 0, 1, 2, 3, 6, 10, 16, and 24th hours. in normoglycemic rats the pet-ether and ethyl acetate fractions of c. cordifolia reduced blood glucose level significantly (39.66% and 40.68% at 16th and 24th hour respectively). in the stz-diabetic rats pet-ether and ethyl acetate fractions also reduced blood glucose level significantly (50.39% and 50% at 10th and 24th hour respectively). ethyl acetate fraction is most effective which reduced total cholesterol level by 31.04% and 36.69% in normal and stz-diabetic rats respectively. ethyl acetate fraction reduced triglyceride level by 43.82% and 42.01% in normal and stz-diabetic rats respectively. our results indicate that pet-ether and ethyl acetate fractions of c. cordifolia have potentiality against diabetes.