|
|
|
|
NEUROPROTECTIVE EFFECT OF VITAMIN C AGAINST PTZ INDUCED APOPTOTIC NEURODEGENERATION IN ADULT RAT BRAIN
|
|
|
|
|
|
|
|
نویسنده
|
NASEER MUHAMMAD IMRAN ,ULLAH IKRAM ,ULLAH NAJEEB ,LEE HAE YOUNG ,CHEON EUN WOO ,CHUNG JONGIL ,KIM MYEONG OK
|
|
منبع
|
pakistan journal of pharmaceutical sciences - 2011 - دوره : 24 - شماره : 3 - صفحه:263 -268
|
|
چکیده
|
The present study was designed to observe the effect of ptz on expression of caspsae-3, and to evaluate the neuroprotective role of vitamin c (vit-c) against ptz-induced apoptotic neurodegeneration in adult rat brain. we observed that administration of a single conclusive dose of pentylenetetrazol (ptz 50mg/kg) in adults rats induced epileptic seizure and increased activation of caspase-3 and caused neuronal death. further, rats were injected with vit-c (250 mg/kg) 30 min before ptz injection. the protective effect of vit-c against ptzinduced apoptotic neurodegeneration in adult rat brain was observed using western blot analysis and nissl staining. the results showed that conclusive dose of ptz-induced seizure, increased expression of caspase-3 and neuronal apoptosis in adult rat brain. whereas, the pretreatment of vit-c along with ptz showed significantly decreased expression of caspase-3 as compare to control group. finally, our results indicated that vit-c can prevent some of the deleterious effect of seizure and neuronal degeneration induced by ptz in adult rat brain.
|
|
کلیدواژه
|
PTZ ,neurodegeneration ,vitamin C ,adult rat brain.
|
|
آدرس
|
Gyeongsang National University, College of Natural Sciences (RINS) and Applied Life Science, Department of Biology, South Korea, Gyeongsang National University, College of Natural Sciences (RINS) and Applied Life Science, Department of Biology, South Korea, Gyeongsang National University, College of Natural Sciences (RINS) and Applied Life Science, Department of Biology, South Korea, Gyeongsang National University, College of Natural Sciences (RINS) and Applied Life Science, Department of Biology, South Korea, International University of Korea, Department of Food Science, South Korea, Gyeongsang National University, Department of Agronomy, South Korea, Gyeongsang National University, College of Natural Sciences (RINS) and Applied Life Science, Department of Biology, South Korea
|
|
پست الکترونیکی
|
mokim@gsnu.ac.kr
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Authors
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|