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HYPOPHAGIC AND HYPOLOCOMOTIVE EFFECTS OF METACHLORO PHENYL PIPERAZINE IN RATS TREATED WITH THEOPHYLLINE AND CAFFEINE
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نویسنده
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ALAM NAUSHEEN ,HALEEM DARAKSHAN JABEEN ,NAJAM RAHILA ,HAIDER SYEDA ,AHMED SHAHIDA PERVEEN
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منبع
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pakistan journal of pharmaceutical sciences - 2011 - دوره : 24 - شماره : 3 - صفحه:251 -254
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چکیده
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Long term intake of coffee is known to produce anxiety and suppression of appetite. 5-hydroxytryptamine (5-ht) acting via 5-ht-2c receptors elicits anorexia and anxiety. the present study is design to monitor metachloro phenyl piperazine (m-cpp) at a dose of 3mg/ml/kg, induces hypophagia and hypolocomotion in rats taking a solution of caffeine (a component of coffee and tea) or theophylline (a component of tea) as a sole source of water. we found that hypophagic and hypolocomotive effects of m-cpp were attenuated in theophylline but not in caffeine treated animals suggesting that long term intake of theophylline may attenuate anorexiogenic and anxiogenic effects of 5-ht. a possible role of 5-ht-2c receptors in the modulation of anxiety and appetite in people drinking coffee or tea discussed.
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کلیدواژه
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Anxiety ,anorexia ,m-CPP ,caffeine ,theophylline.
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آدرس
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University of Karachi, Faculty of Pharmacy, Department of Pharmacology, Pakistan, University of Karachi, Department of Biochemistry, Neurochemistry and Biochemical Neuropharmacology Research Unit, Pakistan, University of Karachi, Faculty of Pharmacy, Department of Pharmacology, Pakistan, University of Karachi, Department of Biochemistry, Neurochemistry and Biochemical Neuropharmacology Research Unit, Pakistan, University of Karachi, Faculty of Pharmacy, Department of Pharmacology, Pakistan
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Authors
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