Effects of propolis on blood biochemical and hematological parameters in nitric oxide synthase inhibited rats by Nω-Nitro-L-arginine methyl ester

This study showed the effects of propolis on biochemical and hematological parameters in chronic nitric oxide synthase inhibited rats by nω-nitro-l-arginine methyl ester (l-name). rats are given l-name for 15 days and the propolis for the last 5 days with l-name together. the levels of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase and gamma glutamyltransferase in the l-name group compared to control group have increased (p<0.05). the levels of these parameters in l-name+propolis group compared to the l-name group have decreased (p<0.05). l-name caused increase (p<0.05) in levels of glucose, albumin, globulin, creatinine, urea, triglyceride and cholesterol. erythrocyte number, total leukocyte, hemoglobin, hematocrit, neutrophil and monocyte decreased (p<0.05), platelets and lymphocyte increased (p<0.05) in l-name+propolis group compared to the l-name group. the study concluded that homeostasis is modulated in l-name administrated rats by adding propolis which causes increasing generation of vascular nitric oxide.