CAFFEIC ACID PHENETHYL ESTER DECREASES THE LEVEL OF S-100B PROTEIN AFTER MIDDLE CEREBRAL AFTER OCCLUSION IN RABBITS

Effects of caffeic acid phenethyl ester (cape) on the serum s-100b levels were studied as an index for brain damage after permanent middle cerebral artery (mca) occlusion in rabbits. twenty rabbits were divided into four groups (n=5): control, sham, non-treatment and cape. the right mca was occluded using a microsurgical procedure with bipolar coagulation and was then transected in non-treatment and cape groups. the rabbits in the sham group underwent a surgical procedure but the mca was not occluded. no surgery was performed in the control group. cape was administered after mca occlusion at the dose of 10μg/kg, once a day intraperitoneally for 7 days in the cape group. serum s-100b levels were determined on days 1, 2, 4 and 7. serum s-100b level was significantly increased following permanent mca occlusion. posttreatment of cape significantly reduced the serum s-100b level. this study demonstrated that cape is capable of attenuating increased serum s-100b level induced by mca occlusion in rabbits. cape may be useful as a neuroprotective agent.