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The effects of taurochenodeoxycholic acid in preventing pulmonary fibrosis in mice
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نویسنده
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Zhou Chuan ,Shi Youfei ,Li Jinlian ,Zhang Wen ,Fu Changqi ,Wang Yanmin ,Liu Yan ,Liu Jianzhu
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منبع
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pakistan journal of pharmaceutical sciences - 2013 - دوره : 26 - شماره : 4 - صفحه:761 -765
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چکیده
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The present study prepared the pulmonary fibrosis model in mice by using bleomycin and carry out the investigations on the effects of taurochenodeoxycholic acid (tcdca) in preventing pulmonary fibrosis in mice. expression profiles of the bile acid receptors in the lung of mice fxrα and tgr5 were examined, and pulmonary coefficient, pathohistology as well as expression of tnf-α, mmp-2, mmp-9 and timp-2 in pulmonary fibrosis mice. the results showed that fxrα and tgr5 simultaneously expressed in the lung of the mice; tcdca in dosages of 0.05 and 0.1g/kg can extremely significantly decrease the pulmonary coefficient in the model mice (p<0.01), tcdca in a dosage of 0.2g/kg significantly decreased the pulmonary coefficient in the model mice (p<0.05); tcdca in dosages of 0.05 and 0.1g/kg significantly reduce the pathological damages on their lungs; tcdca can extremely significantly decrease the expression levels of tnf-α and timp-2 in pulmonary tissues in the pulmonary fibrosis mice (p<0.01), the expression level of mmp-9 extremely significantly increased (p<0.01), while it has no significant effects on mmp2. the results as mentioned above indicated that tcdca had antagonistic actions on pulmonary fibrosis in mice.
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کلیدواژه
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Taurochenodeoxycholic acid; preventing; pulmonary fibrosis; mice
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آدرس
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Shandong Agricultural University, College of Veterinary Medicine, Sino-German Cooperative Research Centre for Zoonoses of Animal Origin of Shandong Province, China, Shandong Agricultural University, College of Veterinary Medicine, Sino-German Cooperative Research Centre for Zoonoses of Animal Origin of Shandong Province, China, Taishan University Tai`an, Department of biological science and technology, China, Shandong Agricultural University, College of Veterinary Medicine, Sino-German Cooperative Research Centre for Zoonoses of Animal Origin of Shandong Province, China, Shandong Agricultural University, College of Veterinary Medicine, Sino-German Cooperative Research Centre for Zoonoses of Animal Origin of Shandong Province, China, Shandong Agricultural University, College of Veterinary Medicine, Sino-German Cooperative Research Centre for Zoonoses of Animal Origin of Shandong Province, China, Shandong Agricultural University, College of Veterinary Medicine, Sino-German Cooperative Research Centre for Zoonoses of Animal Origin of Shandong Province, China, Shandong Agricultural University, College of Veterinary Medicine, Research Center for Animal Disease Control Engineering Shandong Province, China
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پست الکترونیکی
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liujz@sdau.edu.cn
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Authors
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