SUSTAINED OPHTHALMIC DELIVERY OF OFLOXACIN FROM AN ION-ACTIVATED IN SITU GELLING SYSTEM

The poor bioavailability and therapeutic response exhibited by conventional ophthalmic solutions due to rapid pre-corneal elimination of the drug may be overcome by the use of in situ gel forming systems that are instilled as drops into the eye and then undergo a sol-gel transition in the cul-de-sac. the present work describes the formulation and evaluation of an ophthalmic delivery system of an antibacterial agent ofloxacin, based on the concept of ion-activated in situ gelation. sodium alginate was used as the gelling agent in combination with hpc (hydroxy propyl cellulose) that acted as a viscosity-enhancing agent. in vitro release studies indicated that the alginate/hpc solution retained the drug better than the alginate or hpc solutions alone. the formulations were therapeutically efficacious, sterile, stable and provided sustained release of the drug over a period of time. these results demonstrate that the developed system is an alternative to conventional ophthalmic drops, patient compliance, industrially oriented and economical.