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CONFORMATIONAL ANALYSIS (GEOMETRY OPTIMIZATION) OF NUCLEOSIDIC ANTITUMOR ANTIBIOTIC SHOWDOMYCIN BY ARGUSLAB 4 SOFTWARE
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نویسنده
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NAZ AFSHAN ,BANO KHALIDA ,BANO FARHAT ,GHAFOOR NAJAF ABBAS ,AKHTAR NAHEED
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منبع
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pakistan journal of pharmaceutical sciences - 2009 - دوره : 22 - شماره : 1 - صفحه:78 -82
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چکیده
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Showdomycin is a naturally maleimide antitumor antibiotic of the c-nucleoside, it inhibits the nucleic acid synthesis in bacteria. conformational analysis and geometry optimization of showdomycin was performed according to the hartree-fock (hf) calculation method by arguslab 4.0.1 software. the minimum potential energy is calculated by geometry convergence function by arguslab software. the most feasible position for the drug to interact with the receptor was found to be − 0.269696 k.cal/mole.
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کلیدواژه
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Anti-tumor drug ,Showdomycin ,Arguslab 4.0.1 ,conformational analysis ,geometry optimization
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آدرس
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University of Karachi, Department of Biochemistry, Biophysics Research Unit, Pakistan, University of Karachi, Department of Biochemistry, Biophysics Research Unit, Pakistan, University of Karachi, Department of Biochemistry, Biophysics Research Unit, Pakistan, University of Karachi, Department of Biochemistry, Biophysics Research Unit, Pakistan, University of Karachi, Department of Biochemistry, Biophysics Research Unit, Pakistan
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Authors
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