|
|
|
|
DEVELOPMENT AND EVALUATION OF THE SINOMENINE TRANSDERMAL PATCH
|
|
|
|
|
|
|
|
نویسنده
|
WANG JIANPING ,RUAN JINLAN ,ZHANG CHANGGONG ,YE YUJIE ,CAI YALING ,WU YUNXIA
|
|
منبع
|
pakistan journal of pharmaceutical sciences - 2008 - دوره : 21 - شماره : 4 - صفحه:407 -410
|
|
چکیده
|
Sinomenine transdermal patch was prepared and its properties were studied. the patches were produced by salivation method. the releasing rate in vitro of the patch was determined by hplc. peel test was used to evaluate the adhesion. acute skin irritation test was performed in comparison with formalin (0.8%) by using mouse model. the sinomenine tdds patch was prepared. the releasing rate in vitro followed the higuchi equation (r>0.99), the releasing amount was beyond 90% in 24h. the peel adhesion to steel (n/25 mm) is 10 or above. the skin irritation tests showed negligible erythema and edema. the sinomenine transdermal patch was prepared successfully and it may be beneficial for topical use.
|
|
کلیدواژه
|
Sinomenine; transdermal patch; peel test; skin irritation test
|
|
آدرس
|
Huazhong University of Science and Technology, School of Pharmacy, Tongji Medical Center, China, Huazhong University of Science and Technology, School of Pharmacy, Tongji Medical Center, China, Huazhong University of Science and Technology, School of Pharmacy, Tongji Medical Center, China, Wuhan University of Science and Technology, Medical College, China, Huazhong University of Science and Technology, School of Pharmacy, Tongji Medical Center, China, Huazhong University of Science and Technology, School of Pharmacy, Tongji Medical Center, China
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Authors
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|