Synthesis of biologically active O-substituted derivatives of 1-[(3, 5-dichloro-2-hydroxyphenyl)sulfonyl]piperidine

In the present work, a series of 2-o-substituted derivatives of 1-[(3,5-dichloro-2-hydroxy phenyl) sulfonyl]piperidine (5a-j) were synthesized. these derivatives were geared up by the coupling of 3,5-dichloro-2-hydroxy benzenesulfonyl chloride (1) with piperidine (2) under dynamic ph control in aqueous media to form parent compound 1-[(3,5-dichloro-2-hydroxyphenyl)sulfonyl]piperidine (3), followed by the substitution at oxygen atom with different electrophiles (4a-j) in the presence of sodium hydride (nah) and dimethyl formamide (dmf) to give a series of osubstituted derivatives of sulfonamides bearing piperidine nucleus 5a-j. the synthesized o-substituted sulfonamides were spectrally characterized. the bioactivity of all the synthesized compounds were evaluated against lipoxygenase (lox), acetylcholinesterae (ache) and butyrylcholinesterase (bche) enzymes and found to be having talented activity against butyrylcholinesterase enzyme.