ASSESSMENT OF BIOEQUIVALENCE OF CIPROFLOXACIN IN HEALTHY MALE SUBJECTS USING HPLC

Pharmacokinetics and bioequivalence studies of two brands of ciprofloxacin 500mg (ciprofloxacin & ciproxin) were evaluated in 14 healthy male volunteers after oral administration. the drug was analyzed in plasma samples by using hplc. the peak plasma concentrations of (2.28±0.04 mg/l) and (1.9±0.02 mg/l) was attained in about 1.71 hours and 2.00 hours for both test and reference ciprofloxacin, respectively. the mean ± se values for total area under the curve (auc) were 11.91±0.26 and 13.11±0.27 h.mg/l for both test and reference tablets respectively. this study indicated that all the differences in bioequivalence parameters for both ciprofloxacin formulations are statistically non-significant, hence both formulations are bioequivalent.