ANTI-INFLAMMATORY ACTIVITY OF INDANYLTETRAZOLE DERIVATIVES

A number of indanyl tetrazolederivatives namely 5-(6′-chloroindan-1′-yl)tetrazole (cit), 5-(6′- bromoindan- 1′-yl)tetrazole (bit), 5-(6′-chloroindan-1′-yl)methyltetrazole (cimt), 5-(6′-bromoindan-1′- yl)methyltetrazole (bimt) were evaluated for the anti-inflammatory activity in carragennan induced rat paw edema in swiss albino wister rats for 24-hour period at the dose of 100 mg/kg of body weight by intraperitoneal route where phenylbutazone (pbz) was used as the standard. all of these compounds exhibited inhibition on rat paw edema with peak actions observed following 3 hours after administration. moreover, compounds cimt and bimt were further evaluated at dose of 50 mg/kg of body weight. among the compounds, cimt showed higher activity than others and was very close to standard phenylbutazone.