|
|
|
|
PHARMACOKINETICS OF CIPROFLOXACIN IN NORMAL RABBITS AND CHANGES OBSERVED IN INDUCED DEHYDRATED STATE
|
|
|
|
|
|
|
|
نویسنده
|
BASHIR SAJID ,JAMSHAID MOHAMMAD ,AHMAD BASHIR ,IQBAL JAVEID
|
|
منبع
|
pakistan journal of pharmaceutical sciences - 2008 - دوره : 21 - شماره : 3 - صفحه:225 -229
|
|
چکیده
|
The pharmacokinetics of ciprofloxacin following oral administration of a single dose of 20mg/kg body weight was investigated in normal rabbits and changes were observed in water-deprived rabbits. high performance liquid chromatographic method was employed for the determination of plasma concentration of ciprofloxacin. the mean plasma concentration and auc (0-t) and auc (0-inf) were significantly different between normal and dehydrated rabbits (p<0.05), but the absorption rate, distribution rate, and elimination rate did not show any statistically significant difference. the results reflect a need for monitoring toxicity of ciprofloxacin in the water-deprived condition.
|
|
کلیدواژه
|
Pharmacokinetics ,ciprofloxacin ,plasma concentration ,dehydrated rabbits
|
|
آدرس
|
University of Balochistan, Department of Pharmacy, Pakistan, University of Punjab, University College of Pharmacy, Pakistan, University of Punjab, University College of Pharmacy, Pakistan, University of Balochistan, Department of Pharmacy, Pakistan
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Authors
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|