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DEVELOPMENT AND VALIDATION OF HIGH PERFORMANCE LIQUID CHROMATOGRAPHY METHOD FOR ANALYSIS OF SIBUTRAMINE HYDROCHLORIDE AND ITS IMPURITY
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نویسنده
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CHANDORKAR JG ,KOTWAL VB ,DHANDE NS ,PACHPOR MP ,PANDE VV
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منبع
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pakistan journal of pharmaceutical sciences - 2008 - دوره : 21 - شماره : 2 - صفحه:121 -124
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چکیده
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A simple, precise, rapid reproducible and selective reverse phase hplc method has been developed for the estimation of sibutramine hydrochloride monohydrate and its impurity in bulk as well as formulation. the analyte was resolved by using mobile phase (sodium dihydrogen phosphate and acetonitrile) at the flow rate of 1.0 ml/min. on isocratic hplc system consisting of jasco make uv visible detector of model uv 1575 & jasco make hplc pump of model pu 1580.an ods c- 8 rp column (4.6mm id, 250mm l, particle size 5 micron, at wavelength of 230 nm.
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کلیدواژه
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Sibutramine hydrochloride ,impurity*- 5-(2R)-2-aminopropyl)-2-methoxybenzene sulphonamide
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آدرس
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Aarti Drugs Ltd., India, Aarti Drugs Ltd., India, Aarti Drugs Ltd., India, Aarti Drugs Ltd., India, Aarti Drugs Ltd., India
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Authors
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