Synthesis, characterization and biological screening of 5-substituted-1,3,4-oxadiazole-2yl-N-(2-methoxy-5-chlorophenyl)-2-sulfanyl acetamide

In the current study, a series of 5-substituted-1,3,4-oxadiazole-2yl-n-(2-methoxy-5-chlorophenyl)-2-sulfanyl acetamide was synthesized by converting variously substituted/unsubstituted aromatic organic acids successively into the corresponding esters, hydrazides and then 5-substituted-1,3,4-oxadiazole-2-thiols. finally the target compounds were obtained by stirring 5-substituted-1,3,4-oxadiazole-2-thiols with n-(2-methoxy-5-chlorophenyl)-2-bromoacetamide in the presence of n,n-dimethyl formamide (dmf) and sodium hydride (nah). the structures of the synthesized compounds were confirmed based on 1h-nmr, ir and mass spectral data. the synthesized compounds were screened against acetylcholinesterase (ache), butyrylcholinesterase (bche) and lipoxygenase enzymes (lox) and were found to be relatively more active against acetyl cholinesterase.