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Evaluation of anti-inflammatory activity of selected legumes from Pakistan: in vitro inhibition of Cyclooxygenase-2
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نویسنده
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Zia-Ul-Haq Muhammad ,Landa Premysl ,Kutil Zsófia ,Qayum Mughal ,Ahmad Shakeel
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منبع
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pakistan journal of pharmaceutical sciences - 2013 - دوره : 26 - شماره : 1 - صفحه:185 -187
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چکیده
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Crude methanolic extracts of selected legumes namely, black gram (vigna mungo l.), green gram (vigna radiata (l.) r. wilczek ), soybean (glycine max (l.) merr.) and lentil (lens culinaris medik.) were investigated for antiinflammatory effects, using cox-2 producing pge2 inhibitory assay. percentage inhibition observed was 73.93, 79.84, 92.17 and 74.47 for black gram, green gram, soybean and lentil respectively at 20μg/ml extract concentration. the 100μg/ml concentration showed increase in the percent inhibition except for soybean. this is the first report on cox-2 inhibitory potential of food legumes.
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کلیدواژه
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Anti-inflammatory ,legumes ,COX-2 ,lentil ,soybean ,black gram ,green gram
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آدرس
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University of Karachi, Department of Pharmacognosy, Pakistan, Institute of Experimental Botany AS CR, Laboratory of Plant Biotechnologies, Czech Republic, Institute of Experimental Botany AS CR, Laboratory of Plant Biotechnologies, Czech Republic. Czech University of Life Sciences Prague, Institute of Tropics and Subtropics, Department of Crop Sciences and Agroforestry, Czech Republic, Abdul Wali Khan University Mardan, Department of Pharmacy, Pakistan, Bahauddine Zakariya University, Department of Agronomy, Pakistan
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Authors
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