Synthesis, in vitro antibacterial and antifungal activity of some n-acetylated and non-acetylated pyrazolines

Fourteen new n-acetylated and non-acetylated pyrazoline derivatives were synthesized by reacting chalcones with hydrazine in the presence of absolute ethanol however reaction was carried out in the presence of glacial acetic acid to afford n-acetylated pyrazolines. the chemical structures of the synthesized pyrazolines were confirmed by ftir, 1hnmr, 13cnmr and mass spectroscopic data. the pyrazolines (1-14) were screened for antibacterial activity against ten bacterial strains using seven gram-positive and three gram-negative bacteria and antifungal activity against aspergillus flavus, aspergillus niger and aspergillus pterus. pyrazolines (1-14) found to exhibit good to excellent antimicrobial activities compared to the levofloxacin and fluconazole used as standard drugs.