Synthesis and antibacterial screening of S-substituted derivatives of 5-(3,4-methylenedioxyphenyl)-1,3,4-oxadiazol-2-thiol

The most emerging class among the heterocyclic compounds is 1,3,4-oxadiazoles for their diverse biological activities. in the present research work,piperonylic acid (1) was converted consecutively into corresponding ester (2),hydrazide (3) and 1,3,4-oxadiazole (4) through intermolecular cyclization. the synthesized compound 4 was subjected further to s-alkylation/aralkylation,using alkyl/aralkyl halides (5a-m) and s-substituted-1,3,4-oxadiazole derivatives were synthesized (6a-m). the structure elucidation of the synthesized molecules was processed through 1h-nmr,ir and mass spectral data. the antibacterial activity showed these molecules moderately good inhibitors of gram-negative and gram-positive bacteria.