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Analgesic activity of alkyl piperidine derivatives
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نویسنده
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jahan s. ,akhtar s. ,kamil a. ,mushtaq n. ,saify z.s. ,arif m.
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منبع
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pakistan journal of pharmaceutical sciences - 2016 - دوره : 29 - شماره : 1 - صفحه:77 -82
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چکیده
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Piperidine is the most significant scaffold which reveals therapeutic potential because of its conformationally flexible nature. during the course of present investigations synthetic quaternary salts of alkyl piperidine with various phenacyl bromides were explored for their possible analgesic activity. compounds i analogs (1a-1f) and compound ii analogs (iia-iif) showed varying degree of analgesic activity when compared with pethidine as standard and its duration by tail immersion method.
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کلیدواژه
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Alkyl piperidine derivatives; Analgesic activity; SAR
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آدرس
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department of pharmaceutical chemistry,faculty of pharmacy,federal urdu university of arts sciences and technology,karachi, Pakistan, department of pharmaceutical chemistry,faculty of pharmacy,university of karachi,karachi, Pakistan, department of pharmaceutical chemistry,faculty of pharmacy,federal urdu university of arts sciences and technology,karachi, Pakistan, department of pharmaceutical chemistry,faculty of pharmacy,university of karachi,karachi, Pakistan, hej research institute of chemistry,international center for chemical and biological sciences,university of karachi, Pakistan, department of pharmaceutical chemistry,faculty of pharmacy,university of karachi,karachi, Pakistan
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Authors
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