Counter effects of N. Sativa L. and P. ovata L. on indicative markers of non alcoholic fatty liver disease

The broad spectrum of non-alcoholic fatty liver disease (nafld) diseases ranges from simple liver inflammation to steatosis,leading to fibrosis and cirrhosis. four groups of weaning (30g) rattus norvegicus were designated as w-0,w-i,w-ii and w-iii. for sixteen weeks group w-0 was given standard pallet diet,group i consumed diet a (20% fat sucrose + 33% tea whitener + 34% ground pallet diet +13% water),group w-ii was fed on diet b (50g nigella sativa seeds/kg of a) and group w-iii was provided with diet c (50g plantago ovata husks/kg of a). the analysis of cbc,lfts,and lipid profile revealed that there were highly significant changes (p<0.001) in the mcv,plt,hb,mch,mchc,rbc,rdw%,wbc,mpv,triglycerides,cholesterol,ldl and the significant alterations (p<0.01) in albumin,ast,bilirubin,ast/alt,hdl and cholesterol/hdl were observed in the experimental groups when compared with control by using one way anova. we concluded that high-energy diet can alter the blood profile. moreover fat plummeting agents have counter impact on the hematology as well as serology of diet induced nafld in r. norvegicus.